spreadability test of cream

pH of blank and drug-loaded formulations at day 1 and at week 12. The present column explores Transient Receptor Proteins (TRPs), how they sense pain and itch, and their potential application in skin care and anti-aging products. It is one of the most common dermatological conditions encountered in babies while using diapers [5] and is estimated to occur in 735% of babies between the ages of 9 and 12 months [6]. Physicochemical evaluation of selected topical formulations. The observed diameters of the zones of inhibition were measured by using a ruler to the nearest millimeter. Results. After 24 h, the stratum corneum was cut into three pieces of 1 cm 1 cm and stored in a desiccator, which was then placed in a refrigerator.[21]. 9, pp. University of Baroda, Vadodara, Gujarat, India. Test for microbial growth Agar media is prepared, then the formulated cream is inoculated on the plate's agar media by streak plate method and a controlled is prepared by omitting the cream. The site is secure. 12, pp. Method. the mixture design was applied to optimize the cosmetic formula. Antimicrobial activity during the stability study. The values refer to the extent to which the formulations readily spread on the application surface by applying a small amount of shear. The zone of inhibition can be defined as the clear region around the well that contains an antimicrobial agent. Formulation of the gels and creams was followed by evaluating their organoleptic characteristics, physicochemical properties, and in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus. 2, it was kept at room temperature and at an elevated temperature of 45C. The second antibacterial study indicated that both zinc sulfate and copper sulfate have to be present in at least a 3% concentration in order to achieve similar or better results against the tested microorganisms than gentamicin, which was used as the control. The three selected formulations were optimal in terms of their appearance, homogeneity, and viscosity. Several antimicrobial mechanisms of copper were proposed in recent articles, including reactive hydroxyl radical formation leading to damaged cell integrity, denaturation of DNA by binding of copper to protein molecules, and inactivation of enzymes and obstruction of functional groups of proteins from displacement of essential ions [2830]. Results indicated that the antibacterial activity of C1, G1, and G5 was similar to that of the control (gentamicin), while the marketed products had a significantly lower activity against the two tested microorganisms. Out of these four samples, only G5 provided an optimal gel. These gels incorporated the active ingredients well. 2 is stable, without any changes of liquefaction and phase separation. Kumar A, Rama Antiulcer properties of methanolic extract of Benincasa hispida (Thunb.) Received 2011 Jan 3; Revised 2011 Apr 23; Accepted 2011 May 2. In order for Carbomer 940 to form a gel, triethanolamine was added to neutralize the pH to 66.5. No zone of inhibition was observed for the blank, paraben, and 0.1% strength formulations for either the cream or the gels. Using Texture Analysis to Benchmark Cosmetic Quality Advertisements Spreadability. Decline in fluorescence intensities of the cream are given in Table 4, which shows the number of days required for the disappearance. of ml of 0.1 N KOH solution.w = the weight of substance in gram. Hypromellose (Benecel, K4M PHARM, also known as hydroxypropylmethyl cellulose, HPMC), and Prolipid 141 (a mixture of glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, lecithin, lauryl alcohol, myristyl alcohol, and cetyl alcohol) were received as gifts from Ashland (Wilmington, DE). Medium chain triglycerides (MCT) were obtained from Mead Johnson & Company (Evansville, Indiana). 52, no. 6. The suspension was prepared before inoculating the microorganisms on the agar plate. Other parameters that can be measured with this test include the firmness of the cream or its adhesiveness; i.e., ability to stick to a surface. The viscosity of cream was in the range of 499990 to 30000cp which indicates that the cream is easily spreadable by small amount of shear. All formulations maintained their blue color and intensity of color for 12 weeks in all storage conditions. Irritancy, erythema, edema was checked, if any, for regular intervals up to 24hrs and reported. In this Cosmetics R&D Vlog entry, Anne Charpentier, CEO of Skinobs, a digital platform of product testing companies, describes the impact of COVID-19 on cosmetic product testing and discusses how companies are able to move forward. 624626, 1995. Place the base holder on to the base table and lock into position with the screws. Viscosity of creams can be determined by using. As the probe moves into the sample holder, it measures the amount of force required to penetrate the surface of the cream. Lotions are less acceptable to the users than creams. Careers, Unable to load your collection due to an error. 26, no. (4) Preparation of Agar Well Diffusion Assay. Spreadability characteristics of official creams and ointments of the British Pharmacopoeia and the British Pharmaceutical Codex were determined using the Master Curve concept and continuous shear data. The maximum negative force on the graph indicates sample adhesive force; the more negative the value the more sticky the sample. 3, pp. M. Arens and S. Travis, Zinc salts inactivate clinical isolates of herpes simplex virus in vitro, Journal of Clinical Microbiology, vol. Results also confirmed that copper sulfate and zinc sulfate have a synergistic activity, as shown by their larger zone of inhibition against tested microorganisms (). 19331942, 2007. Dong MY, Lumz Yin QH, Feng WM, Xu JX, Xu WM. 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In addition, different product types can be evaluated thanks to various fixtures used with the texture analyzer: lipstick cantilever, eye pencil holder, hair combability fixture, etc. Formulation and Evaluation of Polyherbal Cold Cream - Ijprs Conversely, a lower peak load (firmness) value coupled with a lower hardness work done value indicates a more spreadable sample. The mixture was stored at room temperature overnight for the complete dissolution of lecithin. These four creams had similar consistency, and no apparent change in their physical appearance was observed after adding the metal salts. Dansyl chloride was procured from SRL Chemicals, Mumbai, India. Zinc sulfate and copper sulfate were dissolved in warmed deionized water, and the solutions were added to the cream base using an overhead stirrer (Talboys Engineering Corp, Emerson, NJ). Spreadability test. Spread ability test: The spread ability test showed that the formulated cream has good spreadable property. Formulation and in vitro evaluation of the topical antiageing Formulations C1C4 were formulated with the same ingredients, but with varied concentrations of the emulsifiers and thickeners. This article details how the spreadability test is performed using a texture analyzer. The following graph shows the spreadability of two different types of moisturizing cream. Moisturizing creams serve to keep the skin feeling smooth, soft, looking radiant and healthy by retaining moisture or water in the outer most skin layer. Similarly, the physical appearance, homogeneity, and texture of all formulations remained the same by the end of the storage period. G. Kumel, S. Schrader, H. Zentgraf, H. Daus, and M. Brendel, The mechanism of the antiherpetic activity of zinc sulphate, Journal of General Virology, vol. Spreadability. The following graph shows the spreadability of two different types of moisturizing cream. This instrument is commonly used to take physical measurements because it is relatively affordable, straightforward to use and performs tests in relatively quick timeusually in less than one minute. Determination of pH 5. The screws of the base table can now be tightened. 5, pp. The above cream bases were prepared by accurately weighing the oil phase and the aqueous phase and taking in a beaker separately and heating to about 70C. In addition, structural and viscoelastic characteristics that describe the rigidity, strength and relative contributions of elastic and viscous behaviour play a major role in imparting spreading properties. Triethanolamine was purchased from Making Cosmetics (Snoqualmie, WA). The antibacterial activity of the formulations was compared for samples stored at room temperature (25C) and in the refrigerator (4C) as well as those packaged into glass containers versus plastic containers. [6] According to Raja Nirghantu (an ancient work on therapeutics), medicine from Benincasa hispida was prepared from old, ripe fruits. The spindle was rotated at 0, 0.5, 1, 2, 2.5, 4, 5, 10, 20, 50, and 100rpm values. 2, half portion of the base was kept at 45C and the remaining half was kept at room temperature. Ward, A. 17571761, 2008. Spreadability values for the selected cream (C1) and gels (G1 and G5) compared to various marketed products (. cone sample holder. It has been used as an algicide, germicide, and fungicide for decades. This was then dried overnight in a desiccator by spreading the stratum corneum on a stainless steel wire mesh. As discussed in the introduction, incorporating metal salts into emulsions and gels can be a challenging task for formulators due to the high reactivity of these salts. Medical College, Nagpur, for providing the human cadaver skin for the study. 8, no. The epidermis was then placed in trypsin solution (5% in water) for 5 min. 45, no. 2 showed good diffusibility (average diffusibility 2.05 0.07) than Formula no. 11371142, 2013. Fluorescence intensity of these pieces was checked over a 2-month period to ascertain that the fluorescence did not decline. Position the base table on the base of the machine. 241249, 1993. The body changes that lead to decrease in life expectancy with age are known as senescent, which is the characteristics of living. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, et al. Feasibility study of a cosmetic cream added with aqueous extract and Sterility (For Sterile cream) 3. Moisturizing cream is perhaps the most common personal care product used for moisturizing, rejuvenating, toning, healing and preventing the signs of aging in skin. [15] But, not many scientific studies have been carried out to explore its utility as a skin-renewal enhancer and as an antioxidant. The authors would like to thank the various suppliers for providing samples of ingredients used in the study. We found that the yield stresses for the cream cheese products rose considerably at 8 C to 1500 Pa for . 14, pp. Methanol was recovered under vacuum and the dry extract was obtained (yield 4.2% w/w), which was stored in a desiccator.[16]. The epidermis was then separated by the heat trypsinization method given by Kligman. (PDF) FORMULATION AND EVALUATION OF MOISTURIZING CREAM - ResearchGate 17581762, 2000. 5, pp. BACKGROUND Moisturizing creams serve to keep the skin feeling smooth, soft, looking radiant and healthy by retaining moisture or water in the outer most skin layer.
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