Besides, the compound was reported to possess cytotoxic effects against human nasopharynx carcinoma (KB) cells with an IC50 value of 4.8 M [15]. Unlike before, partitioning in smaller polarity steps did not result in a single active fraction but revealed different activities for TD-1a to TD-1c. Suffice to say that in this patent medicine era, it enjoyed some success. The Mexicans also widely used Damiana as a tonic as it would make people happy, increase vitality and allow them to endure everything. Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats. View abstract. Although Damiana is it's most common name, it also goes by Mexican damiana, Mexican holly, Pastorcita, Hierba . Greek Baby Names Meaning: In Greek Baby Names the meaning of the name Damiana is: One who tames; subdues. This information may not fit your specific health circumstances. Post-run was set to 10 min, temperature to 32 C. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. Results are given in Table 3. Masculine Form Damiano. Interestingly, Chen et al. (Rowland 2003, Szewczyk 2014), Activity against human cancer cell lines has been demonstrated in vitro,(Avelino-Flores 2015, Garza-Jurez 2011, Torres-Gonzlez 2011) and antiaromatase activity has been demonstrated. ; supervision, S.S.. Available for Android and iOS devices. Andrade-Cetto A., Heinrich M. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. HHS Vulnerability Disclosure, Help Copyright 1996-2023 Cerner Multum, Inc. Analysis of the oil has identified a low boiling point fraction composed mainly of 1,8-cineol and pinenes, and a higher boiling point fraction consisting primarily of thymol and sesquiterpenes (eg, copaene, cadinene, calamenene). T. diffusa var. If you choose to use damiana, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Damiana Scientific name: Turnera diffusa. Boege et al. Apart from traditional usage, an aqueous extract of T. diffusa was found to inhibit the monoamine oxidase A with IC50 values of 130 mg/mL as well as the acetyl- and butyrylcholinesterase with IC25 values of 0.352 and 0.370 mg/mL, respectively [8]. Penguin Group. For compound 5 + 6, 7, and 8 stock solutions of 0.04 mg/mL were prepared. View abstract. Viability of NCI-H929 cells 24 and 48 h after treatment with ethyl acetate (TD-1), n-butanol (TD-2), acidified n-butanol (TD-3) fractions and the remaining water layer (TD-4) derived from an acetone (70%) extract of T. diffusa (c,d). For isolation the crude extract was repeatedly partitioned between ethyl acetate and water and the ethyl acetate layer was evaporated to dryness, yielding 32.6 g (TD-1). Using dried herb, you need a 1:5 ratio in 45-60% alcohol. Damiana is a wild shrub prevalent in South America. Zhao J., Pawar R.S., Ali Z., Khan I.A. The margins are recurved and have few serrate teeth. Native to Southwestern Texas in United States, Mexico, Central America, Caribbean and South America. (Arletti 1999), Clinical studies evaluating T. diffusa alone for effects on sexual function are lacking; available studies have evaluated nutritional combination products that, in addition to damiana, included agents such as Ginkgo biloba and Panax ginseng. Conceptualization, S.S.. Turnera aphrodisiaca Ward (synonym T. diffusa Willd., family Turneraceae) is commonly known as damiana. Damia Damiana assist the process of breakdown of sugars an fats in digestive system that enhance the absorption of nutrients. When considering the use of herbal supplements, seek the advice of your doctor. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. The tested fractions were analyzed by UHPLC in order to eventually attribute the observed effects to specific peaks (Figure 4). Study of the anti-hyperglycemic effect of plants used as antidiabetics. aphrodisiaca Common Names Mexican Damiana Spanish: Agita de Damiana, Yerba del Pastor, Pastorcita Cautions None noted. Cell lines were purchased from DSMZ (Braunschweig, Germany) and routinely fingerprinted and tested for mycoplasma negativity. It is a diuretic which helps with relieving incontinence. Damiana enjoys locations that have full sun and dry, rocky soil. Damiana has also been used as an "aphrodisiac" to improve sexual satisfaction or to help with sexual problems. The fluid extract and the crude drug (leaves) were listed in the National Formulary until 1947. 250+ Damiana Stock Photos, Pictures & Royalty-Free Images - iStock Vanaclocha B, Caigueral S. Fitoterapia: Vademcum de Prescripcin 4 ed. Data are shown as mean percentage of viable cells and standard deviation (error bars). You may report side effects to FDA at 1-800-FDA-1088. Ingredient Groups Damiana (Group ID: 191) Category: Botanical Scientific Resources: Damiana (ClinicalTrials.gov) Damiana - Clinical trials (PubMed) Damiana - Dose and administration (PubMed) Damiana - Adverse effects (PubMed) Damiana - Mechanism of action (PubMed) Damiana - Dietary supplement use in human (PubMed) Synonyms/sources: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=22215#null, http://davesgarden.com/guides/pf/go/136721/, http://www.pfaf.org/user/Plant.aspx?LatinName=Turnera+diffusa+aphrodisiaca, https://www.mskcc.org/cancer-care/integrative-medicine/herbs/damiana, http://www.healthline.com/health/damiana-ancient-aphrodisiac#overview1, http://www.webmd.com/vitamins-supplements/ingredientmono-703-damiana.aspx?activeingredientid=703&activeingredientname=damiana, http://www.herbwisdom.com/herb-damiana.html, http://articles.mercola.com/herbs-spices/damiana.aspx, http://www.healthy-r-us.co.uk/Information_Center_damiana.htm, https://healthyfocus.org/the-top-5-benefits-of-damiana/. Skip the missed dose if it is almost time for your next scheduled dose. Koopman G., Reutelingsperger C.P.M., Kuijten G.A.M., Keehnen R.M.J., Pals S.T., van Oers M.H.J. Historically, it was used to promote sexual desire. Select a condition to view a list of vitamins. 27 mg of acacetin 7-O-methylether (9) and another 58 mg of linoleic acid were obtained from TD-1_4 by preparative column chromatography using 0.025% formic acid in water and methanol in a gradient matter. Regression curves, coefficients of determination, limit of detection (LOD), and limit of quantitation (LOQ) of the UHPLC method. [26], "Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward", "Taxonomic Clarification on Turnera diffusa Ward and its Demarcation from "False Damiana" using Fluorescence, Scanning Electron Microscopy, HPTLC and UPLC", "Damiana - Turnera diffusa, Turnera ulmifolia seed pictures", "Turnera diffusa var diffusa or var aphrodisiaca or what? Nevertheless, though flavonoids are generally assumed safe due to regular uptake with fruits and vegetables, they were found to evoke cytotoxic effects at higher doses [27,28]. Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis. Confirmatory research is needed. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The name Damiana is girl's name of Greek origin meaning "tame, domesticated". View abstract. Damiana is found growing in hot and humid climates such as: Texas, southern California, Mexico, Central America, the northern Caribbean Islands and Namibia in USDA growing zones of 8, 9, 10 & 11. Our bioactivity-guided approach led to the isolation of seven flavonoids and a mixture of acacetin and genkwanin (Figure 1, 19). Alcaraz-Melendez L, Delgado-Rodriguez J, Real-Cosio S. Analysis of essential oils from wild and micropropagated plants of damiana (Turnera diffusa). We comply with the HONcode standard for trustworthy health information. Treat sexual problems, Calms mind, Cure stomach ulcers, Supports weight loss, Treat infections, Damiana Leaves, Wild Countryside Damiana Leaves, herba de la pastora, old womans broom, Mexican damiana, oreganello, the bourrique, 1-2.5 cm long, 6 mm wide, smooth, pale green, ovate to lanceolate, Yellow, axillary, solitary, small, aromatic, Plantae (Plantes, Planta, Vegetal, plants), Tracheophyta (Vascular plants, tracheophytes), Turnera diffusa Willd. Damiana is a shrub belonging to the Passifloraceae family that bears small and aromatic flowers when it reaches upto 2 meters in height. Bernardo J., Ferreres F., Gil-Izquierdo ., Valento P., Andrade P.B. Sample Availability: Samples of the compounds 5 + 6 and 7 are available from the authors. This aromatic shrub is native to Tropical America, from Mexico to South- America and the Caribbean. The red-brown twigs are often found mixed in the crude drug along with its spherical fruits. Bethesda, MD 20894, Web Policies It produces small yellow flowers and blossoms throughout the summer. Apart from the presence of a few peaks in the more polar region, TD-1b showed higher amounts of compounds 58 and lower concentrations of compounds 2 and 9. (Rowland 2003), Avoid use. The authors thank Matthias Mayr for conducting the cytotoxicity assays. Traditional/Ethnobotanical uses Mexican Damiana - Medicinal Herb Info The calibration curves for quantified constituents 4 to 8 were obtained on five levels each regarding the concentration of the corresponding analyte in the extract. Privacy Policy Our Ingredients - houseofwarisbotanicals ex Ham.) It bears small, aromatic flowers that bloom in early or late summer. Avelino-Flores Mdel C, Cruz-Lpez Mdel C, Jimnez-Montejo FE, Reyes-Leyva J. Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. d. var. Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. Vector illustration of pirandai or veldt grape . Damiana is from the Turneraceae family. (Rowland 2003), Alkaloids, cyanogenic glycosides, steroids, saponins, flavonoids, tannins, carbohydrates (saccharides), and proteins have been identified in the plant. They used the herb to flavor teas and drinks. (Duke 2002, Khan 2010, Szewczyk 2014), Damiana was included in the first edition of the National Formulary in 1888 as an elixir and fluid extract. Damiana | Memorial Sloan Kettering Cancer Center The sample of a traditional preparation of T. diffusa revealed minor compounds in the medium to low polarity range and a high content of polar compounds. Meaning, origin and history of the name Damiana Shatavari Scientific name: Asparagus racemosus. It also possess damianin, gonzalitosin I, tetraphyllin B, arbutin, acacetin, tricosan-2-one, p-cymene, -sitosterol, apigenin, -pinene, -pinene, -carotene, eucalyptol, thymol and hexacosanol. found that the anti-inflammatory effect of velutin (7) against periodontitis is caused by an inhibition of HIF-1 expression [14]. The volatile oil in damiana might be sufficiently irritating to the urethral mucous membranes to account for its so-called aphrodisiac effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is used in traditional medicine as a diuretic, laxative . - Damiana, nettles, and parsley seed for prostate health support. It also gives a mild narcotic 'high' that usually lasts around an hour. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, GUID:85BD1B46-ED13-4CA1-AEC1-5FE23BC8E7BB, multiple myeloma, quality control, naringenin, flavonoids, traditional preparation, Arbo M.M., Espert S.M. Investigation of the cytotoxic properties of T. diffusa revealed significant effects for different apolar extracts against the myeloma cell lines MM1S, U266 and NCI-H929. Additionally, for all quantified constituents 0.25 mL of the lowest level of the calibration curve was added to 0.75 mL of the extract. Post-run was set to 10 min, temperature to 32 C. (Kumar 2008, Kumar 2005a, Sarris 2013) In the hippocampus of rats, a hydroalcoholic extract of T. diffusa had no effect on cell death (apoptosis). In contrast, TD-1a was less active against these two cell lines. Today, damiana has found its way into a number of herbal OTC products, in particular those claiming to induce a legal herbal "high.". There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. 2021 Healthbenefitstimes. Cyanogenic glycosides may be present; there is a risk of cyanide toxicity with high doses of damiana. could not find any hypoglycemic effect of an ethanol-water extract [6], Parra-Naranjo et al. However, these uses have not been proven with research. Damiana Uses, Benefits & Dosage - Drugs.com Herbal Database Avoid using damiana together with other herbal/health supplements that can lower blood sugar, such as alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others. The established method was additionally used for the analysis of a traditional preparation of T. diffusa (Figure 7). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Damiana showed anxiolytic(1)(17), antidepressant(17), hypoglycemic(7)(9), anti-ulcer(15) as well as cytotoxic(16) effects; and stimulated sexual behavior(3)(13)(14) in preclinical models. 1 Concentrations are given in g/mL, relative standard deviations are given in parentheses and are stated in percent. Introduction. It blossoms in early to late summer and is followed by fruits that taste similar to figs. Scientific Name(s): Turnera diffusa Willd. This is not a complete list of side effects and others may occur. Anti-aromatase activity of the constituents from damiana (. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Damiana - wa.kaiserpermanente.org pcog lecture - resins Flashcards | Quizlet Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Damiana is a Mexican shrub also found throughout the southern US and many parts of South America. Do not take damiana without medical advice if you are using any of the following medications: This list is not complete. Version: 5.01. In diabetic patients, it might interrupt with the blood sugar. Centrifugation was performed on a Heraeus Megafuge 16 (Thermo Fisher Scientific Inc., Waltham, MA, USA). UHPLC analysis of the three fractions of the second partitioning step (TD-1a to TD-1c) resulted in similar findings. Linearity was achieved by five-point calibration with a coefficient of determination of >0.99 (Table 1). After flowering, damiana grows a fruit that tastes very much like figs. Use tab to navigate through the menu items. Damiana extracts with tequila are allegedly used as love potions [3]. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. 1995, Hutchens, Alma R. Indian Herbalogy of North America. sharing sensitive information, make sure youre on a federal The authors declare no conflict of interest. The preparation of Damiana is useful for treating sexual disorders and prophylaxis. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. (Kumar 2008, Szewczyk 2014), One study reported hypoglycemic effects in mice with oral administration of an aqueous extract of T. FOIA (Szewczyk 2014) Damiana's current popularity is related to its purported aphrodisiac and hallucinogenic properties, despite a lack of documented evidence. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 25 June 2023), ASHP (updated 11 June 2023) and others. Williams R.J., Spencer J.P.E., Rice-Evans C. Flavonoids: Antioxidants or signalling molecules? 8600 Rockville Pike Other drugs may interact with damiana, including prescription and over-the-counter medicines, vitamins, and herbal products. Vector illustration of pirandai or veldt grape, scientific name Cissus quadrangularis, isolated on white background. - Use damiana with skullcap and lemon balm for a calming, nervous restorative. (Szewczyk 2014, Zhao 2008) Limited studies in rodents have demonstrated positive effects of T. diffusa on sexual behavior. National Library of Medicine Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Documented adverse effects include risk of cyanide toxicity (due to cyanogenetic glycosides components) in high doses. Intake the capsules that contains the mixture of Yerba Mate, damiana and Guarana assist weight loss. Scientific Back Up Sadly, we do not know how Damiana works. The stems and leaves are used for infusion or flavoring. ), 2Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria; ta.ifkt@rerheoj.nirak (K.J. Damiana contains damianin; tetraphyllin B; gonzalitosin I; arbutin; tricosan-2-one; acacetin; p-cymene; -sitosterol; 1,8-cineole; apigenin;[10] -pinene; -carotene; -pinene; tannins; thymol;[11] and hexacosanol. (Taha 2012). Cytotoxic assays of the pure compounds resulted in the identification of two compounds (1 and 4) with significant impact on cell viability (Figure 5). Other Common Names: The other common names for the shrub damiana are Mexican damiana, Mexican holly, herba de la pastora and old womans broom. Xie C., Kang J., Li Z., Schauss A.G., Badger T.M., Nagarajan S., Wu T., Wu X. Anti-anxiety Activity Studies on Homoeopathic Formulations of Turnera aphrodisiaca Ward. The cytotoxicity of naringenin is in line with previous findings, if however, observed for other cell lines [25,26]. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Damiana is a wild shrub prevalent in South America. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. The red-brown twigs often are found mixed in the crude drug along with the spherical fruits. and C.Z. Fitoterapia 2004;75:696-701. Prescription for Herbal Healing, Second edition. As a library, NLM provides access to scientific literature. Regarding the antidiabetic activity, conflicting results were obtained. The established calibration curves had determination coefficients of more than 0.99 and were thus accepted for quantification purposes. The damiana margarita is popular in the Los Cabos region of Mexico.[7][8]. diffusa, Damiana is a relatively small, woody shrub that produces small, aromatic flowers. Three concentration levels (25, 50, 100 g/mL) are shown. Post-run was set to 10 min, temperature to 32 C.